Acute kidney injury (AKI) is a common cause of morbidity and mortality rates in critically ill patients requiring intensive care therapies . Approach to the treatment of AKI patients requiring dialysis has gone under evolution with the advent of chronic renal replacement therapies (CRRT) over the last two decades. Critically ill and hemodynamically unstable children better tolerate CRRT than the traditional hemodialysis.CRRT provides a slow and gentle fluid removal from body much like the native kidneys and removes inflammatory mediators of sepsis such as interleukin, TNF-alpha, and complement. CRRT also provides adequate nutritional support for the catabolic AKI patients and a control desired fluid balance.In this book, we review the current understanding of CRRT techniques, with focus on drug dosing in critically ill children receiving CRRT. The effect of CRRT on drug pharmacokinetics, which provides guidelines whether or not dose adjustment is required, is also provided in an accompanying reference table. Variations in the drugs properties regarding their molecular weights, dialysis and blood flow rates, dialysis membranes are discussed. The drugs
The book also provides a simple and easy method for estimating drug clearance as a function of total creatinine clearance when the information on the pharmacokinic of a particular drug is not available.